Cannabidiol appeared safe and more effective than placebo at lowering cannabis use, according to results of a randomized clinical trial published in The Lancet Psychiatry.
Although results of a meta-analysis of randomized clinical trials suggested cannabidiol was safe and well-tolerated, as well as associated with few adverse effects, it may interact with other medications and should thus be carefully monitored because of its potential role in inhibiting cytochrome P450 enzymes, according to the researchers. To their knowledge, no randomized trials have evaluated cannabidiol as a potential treatment for cannabis use disorder.
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