Omega-3s as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.
The efficacy of omega-3s on microbial cell membranes and their antioxidant properties have been shown to inhibit the growth of microorganisms and thereby promote human health and animal health. Hence, they can be considered as potential alternative or adjunctive therapeutic agents because of their antimicrobial and immunomodulatory properties. Since the development of antimicrobial resistance outruns antimicrobial drug development, it is worthwhile to consider omega-3 FAs in the list of potential antimicrobial agents.