Twenty years ago this year, former Massachusetts Institute of Technology researcher Dr. Barry Sears published Enter the Zone: A Dietary Road Map, a book that helped change the discussion about diet and health. Against the established nutritional powers–still clutching the “high carb, low-fat” mantra–Sears championed what he called an “anti-inflammatory” dietary approach to undermining obesity and a host of chronic diseases, including diabetes, cardiovascular disease and brain-based diseases. At the time, little was being said about the connection between diet and diseases like Alzheimer’s and Parkinson’s, but Sears pointed to trends in the modern American diet that were fueling the expansion of these and other conditions.