Researchers out of France and Monaco recently finished one of the longest and largest studies on Alzheimer’s disease. The study focused on using multidomain lifestyle intervention with Omega 3 supplementation for Alzheimer’s patients. Researchers tested the effect of omega 3 supplementation and a multidomain intervention (43 group sessions integrating cognitive training, physical activity, and nutrition, and three preventive consultations; two capsules a day of omega 3s providing a total daily dose of 800 mg DHA and 225 mg EPA), alone or in combination, compared with placebo, on cognitive decline.
The results, unfortunately, were statistically insignificant, but show potential for new treatment approaches that are less expensive, easier to implement, and safer. All three groups showed improvement over the placebo group. The primary outcome was change from baseline to 36 months on a composite Z score combining four cognitive tests (free and total recall of the Free and Cued Selective Reminding test, ten Mini-Mental State Examination orientation items, Digit Symbol Substitution Test, and Category Naming Test) in the modified intention-to-treat population.
[NOTE: This is one of my biggest issues with such research: the doses of omegas, in my opinion are less than half of what they should be in order to actually make a difference.]