Rheumatoid arthritis (RA) may be effectively treated with the lipid mediator resolvin D1, a metabolite of omega-3 fatty acids, according to a study that found a pronounced easing of the disease in mice after treatment. The study, “Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis,” was published in JCI Insight.
“The results we present here using synthetic RvD1 as a prototype therapeutic tool from the SPM portfolio, a choice dictated by detection of this bioactive mediator in mouse and human joints, opens the opportunity to exploit this line of research for innovative therapeutic strategies in RA that combine potent anti-inflammatory with tissue-protective properties,” the researchers concluded.