Treatment with omega-3’s may help reduce symptoms of anxiety, according to a new study published in JAMA Network Open. The review and meta-analysis tapped data from 19 clinical trials which included 2240 participants (1203 treated with omega-3 PUFAs and 1037 without) from 11 countries. “Although participants and diagnoses were heterogeneous, the main finding of this meta-analysis was that omega-3 PUFAs were associated with significant reduction in anxiety symptoms compared with controls,” researchers wrote. “This effect persisted vs placebo controls.”
Researchers also discovered daily dosages higher than 2000 mg were linked with a significantly higher anxiolytic effect, compared with lower dosages. In addition, supplements with less than 60% eicosapentaenoic acid (EPA) were significantly associated with reduced anxiety symptoms, but supplements with 60% or more EPA were not. “The depression literature supports the clinical benefits of EPA-enriched formulations (≥60% or ≥50%) compared with placebo for the treatment of clinical depression,” researchers noted. “This opposite effect of EPA-enriched formations on anxiety and depression is intriguing and possibly linked to a distinct underlying mechanism of omega-3 PUFAs.”
Read more at: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2702216