A team of biomedical engineering researchers at the University of Arkansas published in Nature’s Scientific Reports that have identified a cause of fluid swelling of the brain, or cellular edema, that occurs during a concussion. “Our study found that mild traumatic brain injury resulted in increased expression of a protein called aquaporin-4, which caused a massive cellular influx of fluid, leading to increased astrocyte cell volume and injury,” said Kartik Balachandran. “We then worked with a drug called Acetazolamide. Our results showed that Acetazolamide minimized cell swelling and injury, suggesting a therapeutic role for this drug in reducing the detrimental effects of concussions.”
The researchers engineered a benchtop bioreactor to examine astrocyte cells. This device helped them see that mild traumatic brain injury led to an increased expression of aquaporin-4, the protein that causes a large cellular influx of fluid, which in turn leads to increased astrocyte cell volume. “This study demonstrates the collaborative neuro-engineering efforts that are contributing to both diagnostic and therapeutic methods for addressing traumatic brain injury,” said Raj Rao, professor and chair of the Department of Biomedical Engineering at the University of Arkansas.
Read more at: http://www.news-medical.net/news/20161122/Scientists-identify-potential-drug-for-pre-treating-cells-that-swell-after-mild-traumatic-brain-injury.aspx