Drug Interactions
The following products have been investigated in clinical drug–drug interaction studies with the RxOM3FAs [prescription omega-3 fatty acids]: warfarin (Vascepa, Epanova); omeprazole (Vascepa); rosiglitazone (Vascepa); atorvastatin (Lovaza, Vascepa, Omtryg); rosuvastatin (Lovaza, Omtryg); and simvastatin (Lovaza, Omtryg, Epanova).1–4,23–28 No drug–drug interactions were observed. The package inserts for all RxOM3FAs note that patients who are receiving drugs that affect coagulation should be monitored periodically because prolongation of bleeding time has been noted in some published studies of OM3FAs.1–4 However, the package inserts note that the prolongation of bleeding time in those studies did not exceed normal limits and did not produce clinically significant bleeding episodes. Furthermore, evidence-based reviews have concluded that OM3FAs do not increase the risk of clinically significant bleeding, including in patients receiving medications that affect coagulation.29–31
Read the original article at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671468/